HERA will identify and trade-off the concept of a regional aircraft and its key architectures. Additionally, the required aircraft-level technologies will be developed and integrated into the required enablers to meet the -50% technology-based GreenHouseGas (GHG) emission set in Strategic Research and Innovation Agenda (SRIA) for a Hybrid-Electric Regional Aircraft. The HERA aircraft, having a size of approximately 50-100 seats, will operate in regional and short-range air mobility by mid-2030 on typical distances of less than 500 km. The aircraft will be ready for future inter-modal and multi-modal mobility frameworks for sustainability. The HERA aircraft will include hybrid-electric propulsion based on batteries or fuel cells as energy sources supported by SAF or hydrogen burning for the thermal source, to reach up to 90% lower emissions while being fully compliant with International Civil Aviation Organization (ICAO) noise rules. The HERA aircraft will be ready for entry into service by mid-2030, pursuing the new certification rules, able to interact with new ground infrastructure, and supporting new energy sources. This will render HERA aircraft as sustainable, safe, and fast connectivity mean, with low GHG emissions, ready for actual revenue service offering to operators and passengers. HERA will quantitatively trade innovative aircraft architectures and configurations required to integrate several disruptive enabling technologies including high voltage MW scale electrical distribution, thermal management, new wing, and fuselage as well as the new hybrid-electric propulsion and related new energy storage at low GHG. To support this unprecedented integration challenge, HERA will develop suitable processes, tools, and simulation models supporting the new interactions, workshare in the value chain, and interfaces among systems and components. HERA will also elaborate on the future demonstration strategy of a hybrid–electric regional aircraft in Phase 2 of Clean Aviation to support the high Technology Readiness Levels (TRL) demonstration required for an early impact for HERA solutions.